ImplantSens will not only contribute to the painless long term monitoring of glucose levels for diabetic patients, but also to the development of future implantable sensors for the management of other chronic diseases. In order to develop such biosensors, there is the possibility to develop co-axial porous sensor architectures following a hard template approach, which will serve as a platform for the immobilization of enzymes operating either in direct or mediated electron transfer mode. The electrocatalytic behavior in terms of charge transfer and mass transport properties will be characterized in order to optimize the performance of the sensor which will undergo in-vivo testing in order to assess toxicity and biocompatibility.